Comments on: MTHFR, Folic Acid and Folate: Should I Eat It?

By: BThomas

BThomas — Wed, 18 Apr 2018 19:21:00 +0000

Just because you have an MTHFR mutation(s) doesn’t mean eating extra folate will help. Sometimes, depending upon whether your system is overmethylating or undermethylating, folate with have positive or deleterious effects. It is not wise to suggest ALL people with MTHFR to load up on folate. In undermethylators the excess folate can speed up the SERT function, that is the serotonin transporter. When SERT is speeded up, it takes the serotonin out of circulation and the result is depression. I have inadvertently done this without supplementation, only with whole fresh foods. I would advise caution in high consumption of folate rich foods or methylfolate supplementation for people with MTHFR C677T. In some people folate helps with depression, in others it can make it worse.

By: leeann

leeann — Thu, 15 Mar 2018 11:03:00 +0000

hello how are you, if you take anything supplemental make sure it is in its converted stage (folate opposed to folic acid) (b12 in methyl form) very few doctors are educated on this matter I am going to see a geneticist that understands mthfr, don’t listen to doctors that are not sure exactly it could be dangerous if untreated or mistreated

By: julie

julie — Thu, 21 Dec 2017 15:26:26 +0000

In reply to Mary.

Hi Mary.

Do you know the specific tests that determined which prescription drugs your children cannot take. My daughter has MTHFR A1298c mutation and was tested deficient in folate among other nutrients. She sleeps all day and I am trying to find the right supplement combination for her. I wonder if her birth control or anziety medicine are playing a role in all of this.

Julie

By: Joe Leech, Dietitian

Joe Leech, Dietitian — Fri, 08 Dec 2017 21:40:44 +0000

In reply to shaunte Forte. Hi Shaunte, I don't recommend injecting B12 or folic acid. And you should speak to your doctor about that.

By: Ally

Ally — Wed, 29 Nov 2017 22:05:36 +0000

In reply to Aelxa Hill.

I am homozygous for C677T and recent lab results showed low (below normal) levels of folic acid and B12. My doctor gave me a Cyancobalimin b12 shot. Will this type work for those with MTHFR mutations?

My doctor recommended I take a folic acid supplement, but I’m hesitant to do so given what I’ve read about problems being able to convert folic acid. Is there a specific type of supplement I should be taking? From what I’ve read, increasing folic acid in foods like spinach should help, but won’t be enough. Appreciate any advice.

By: Joe Leech, Dietitian

Joe Leech, Dietitian — Tue, 28 Nov 2017 23:14:48 +0000

In reply to Robin. Hi Robin, MTHFR does not effect weight gain to my knowledge. I can't see how that mutation would effect your weight.