Comments on: MTHFR C677T and A1298C: Explained In Plain English

By: Bonnie

Bonnie — Thu, 26 Feb 2026 04:04:06 +0000

What is difference between anemia and iron deficiency anemia? I don’t have anemia but I don’t think I have been tested for iron deficient anemia. Not sure if relevant but I think I have compound heterogenous version. Therapist says I have 1 copy of each variant, I take 15 mg l-methylfolate and methylated B12. The methylfolate has lifted my tendency toward depression greatly. (I am lax on the vitamin B12.) No vitamins or other supplements. General suggestions on vitamins and supplements? here’s my “biggie”: I have debilitating fatigue which I have attributed to stage 3b kidney damage and mild diastolic dysfunction, and those are likely the chief drivers of the fatigue, but would my 1 copy of each variant possibly be contributing to the fatigue? It is so bad that my doctor has prescribed Nuvigil, a drug that I think is primarily for narcolepsy. Incidentally I had a B6 shot a few months that incredibly lifted my mood, but subsequent shots have had no effect. Many thanks for any guidance you can give. .

By: Betty

Betty — Mon, 23 Feb 2026 02:39:25 +0000

I have compound of both. My Dr was baffled and where I live it seems no Doctors here have a clue other than testing. It is scary as I am 42,smoker . I have has 1 still birth,my second was born with Cerebral palsy, 3rd kid is fine but my 4th and last was born with a HRHS and passed away at 2 weeks old after second open heart surgery. I feel this mutation has played a huge role . Also I preclampsia with my second,almost died. I wish I could find a Dr who could give me better insight. Im scared to travel for fear of blood clots,I have been battling depression my whole life and now I have 0 energy. I jist need help and answers.

By: Lisa

Lisa — Mon, 12 Jan 2026 06:29:55 +0000

Hi, I have Homozygous MTHFR C677T, but I also have Dysautonomia Trifecta(Ehlers-Danlos, POTS, and MAST Cell Activation Syndrome). I’ve been really struggling. Passing out several times a week. Actually I was taken by ambulance yesterday morning, because I was going in and out of consciousness. With odd muscle and nerves jumping. They treated my BP, and said it eas a “POTS FLAIR UP.”I also have Pulsatile Tinnitus, that gets worse when my BP goes really high, or drops low too fast. I have lasting injuries in my knees that both require at least 2 more surgeries. Plus falling has caused ugly scars. Thankfully I’ve only hit my head twice, once was minor, and the other was a mild concussion. I have literally been tested for everything, that the local doctor’s can think of. So, after doing tons of my own research, my main question is… Is there a connection between Homozygous MTHFR C677T, and Dysaunomia Trifecta? I’m desperate for answers. I honestly feel like this is gonna kill me if I fall and cause a traumatic injury. I’ve basically been bed ridden and wheelchair bound for about 3yrs. I just turned 48, and my first grandbaby is almost 1.5yrs old. I will never keep her by myself, and it truly breaks my heart.

By: Vicky Moore

Vicky Moore — Fri, 24 Oct 2025 16:44:04 +0000

I’m going to share this for awareness purpose. Living with Herpes simplex was depression for me even with my doctor’s advice and medication. My name is Shirley Moore I live in Chicago, Illinois and this is my story. I browsed the Internet in search of remedies or something but unfortunately nothing new, all still had the same results. Sadly I almost quit on myself, it was around 7:30 in the morning when my therapist called me over to her house, at first I was skeptical, but I went anyways on getting there she was smiling and said there’s living proof now, she showed me a lady who also suffered from herpes simplex 3years back and now she is cured by a doctor who also studied natural herbs. I was amazed and lost for words I even doubted but showed me a doctor’s report test. So I contacted the doctor and weeks later, I was cured. So I would love to use this medium to say a big thank you to my therapist and Dr. Chalopa. This story is shared to others like me out there. However, he also treats other illnesses.

E mail (drchalopa @ gmail. com)

By: Watona RoBards

Watona RoBards — Sat, 18 May 2019 05:36:36 +0000

I was first told I had MTHFR and she put me in the methyl forms of B-12 and Folic Acid. Then later the doctor said I did not have that, but I had MTRR. She told me to add folic acid because that is the form of folate which crossed the brain barrier. What is the difference of these two genetic mutations and howyou treat them? Thank you.

By: jessica

jessica — Thu, 14 Mar 2019 13:08:16 +0000

Hello,
I’m looking for some advice on my following results for my 1 year old

MTHFR C677T risk allele A my allele AG +/-

MTHFR C10318T risk allele G my allele GG +/+

MTHFR A4598G risk allele A my allele AA +/+

I’m not sure what they mean or what risks they are or things we should avoid, can you vaccinate with these mutations?

We are in england, are there any doctors near london that could help ?

Any advice would be much appreciated

Thank you
Jess