Comments on: L-Methylfolate (5-MTHF): Your Must-Read Beginner’s Guide

By: C Go

C Go — Wed, 10 Dec 2025 18:46:19 +0000

I just found out Im pos for MTHFR. My MVCs have been hx v small, ferritin low (3-9) and I found a bio avail iron+ supplement, w B12, and recommended amount is 1 pill, I must take three daily to sustain a decent ferritin level….my B12 is 1,600. We check my iron panel Q3-6 months to ensure I am not OD on Fe…. My provider said to start on Methyl Folate 5mg…I order two bottles: one with 1,000mg and one with 1,700mg….. I m reading others w pos MTHFR (apparently there are two variations? I will need to see which one/s I have).

Hashimotos around age 34. Intermittent depression, brain fog at 38 and late life ADHD formal dx age 39….could have really used and formal dx for ADHD MUCH earlier in my life. Last year, sleep issues very severe, and post exertion malaise. I lift and work out 3-6 days a week, eat macro balanced, and some weeks I can only go like 1 time a week due to fatigue, most months, 4-6 feels amazing and clearer mentation as well…can MTHFR fluctuate impact?

I have plenty of B12, I am wondering if starting on 1.7 g is a horrible idea? I feel fatigued, so many symptoms , apparently this is related to the ferritin anemia issues as well? (my iron is solid, and my H&H are just above WNL) and I want to improve. Is methyl folate something that a loading dose would be a good idea with? considering it is excreted in urine?

Very interested in learning more.

By: Alan

Alan — Tue, 18 Sep 2018 17:17:00 +0000

Do you have references for some of the claims made? For example high doses of l-methylfolate can lead to cancer? I have searched pubmed and have come up dry for any primary literature that would validate that claim. However, I am not an expert in primary literature search yet, I just finished my PharmD so I’m still relatively new.

By: Stephanie

Stephanie — Sat, 15 Sep 2018 16:34:00 +0000

Thanks for your articles, I have read a lot and you have really clarified concepts for a non science graduate.

However, you state to be cautious of overmethylation caused by taking L-methylfolate. In Walsh’s book the very definition of overmethylation is folate deficiency. So don’t you mean there is risk of becoming undermethylated?

By: laura wetherald

laura wetherald — Mon, 30 Jul 2018 17:55:00 +0000

I bought this as it was supposed to help with hearing loss. I do not see this in any of this info???

By: Kjell L

Kjell L — Wed, 06 Jun 2018 11:20:00 +0000

Supplementing only methylfolate does not increase homocystein levels. Also, if not deficient in vitamin B6, homocystein will be converted to taurine / cystein via the normal pathway. Low B12 levels are in no way a risk factor for supplementing methylfolate. Please stop writing articles. Chances are somebody will become sick because of ambiguous information.

By: SayUwantRevolution

SayUwantRevolution — Thu, 01 Mar 2018 11:43:00 +0000

In reply to Mike. Not true. or accurate. A diet high in leafy greens, like spinach, can be a substitute for L-Mrethylfolate.