Folate and folic acid are nutrients required for many critical functions in the body. Unfortunately, many who have a genetic MTHFR mutation are unable to utilise these nutrients properly. L-Methylfolate (5-MTHF) has emerged as a popular alternative, and has been used as a complementary medicine in several recent clinical trials. This article covers what you need to know about it, but explained in human terms. What is L-Methylfolate (5-MTHF)? L-methylfolate is the biologically active form of vitamin B9. That means it is the form the human body can actually use in circulation. It goes by several other common names including: The letters or numbers before the name refers to the 3D chemical structure of that compound. In this case all you need to know is that L- and 6(S)- indicates biologically active L-Methylfolate (helpful). D- and 6(R)- indicate non-biologically active L-Methylfolate (not helpful). Some products may only … Continue reading L-Methylfolate (5-MTHF): Your Must-Read Beginner’s Guide